STAT-3/c-Src-IN-1 (Compound 12d) is a dual STAT-3 (IC50=0.844 µM) and c-Src (IC50=0.268 µM) inhibitor. STAT-3/c-Src-IN-1 blocks tumor cell proliferation, migration, and angiogenesis signaling pathways. STAT-3/c-Src-IN-1 exhibits potent anti-proliferative activity against melanoma (SK-MEL-2) and CNS cancer (SNB-75) cell lines (GI50=-5.75 µM and -5.63 µM), inducing tumor cell apoptosis via G0/G1 and G2/M phase cell cycle arrest. STAT-3/c-Src-IN-1 is promising for research of melanoma and glioblastoma[1].
Molekulargewicht:
585.59
Formel:
C28H23N7O6S
Target-Kategorie:
Apoptosis,Src,STAT
Anwendungsbeschreibung:
MCE Product type: Reference compound1
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
