MLS6357 is a D3 dopamine receptor (D3R)-selective positive allosteric modulator (PAM)-antagonist. MLS6357 exhibits antagonist activity in the D3R-mediated and the BRET-based beta-arrestin recruitment assay with IC50s of 13 and 14 µM, and no activity for other DAR subtypes (D1R/D2R/D4R/D5R) (IC50 > 100 µM). MLS6357 is also an antagonist in the D3R-mediated Go-BRET assay with an IC50 of 17 µM. MLS6357 can be used for the study of neuropsychiatric disorders, including substance use disorder[1].
Molekulargewicht:
395.90
CAS Nummer:
[932544-59-7]
Formel:
C18H22ClN3O3S
Target-Kategorie:
Dopamine Receptor,PERK
Anwendungsbeschreibung:
MCE Product type: Reference compound
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