TREM2 agonist-5 is the microglial lipid-sensing receptor (TREM2) agonist with a Kd of 71.36 µM. TREM2 agonist-5 is a racemic structural analog of the TREM2 agonist VG-3927 and exhibits superior microglial phagocytosis and activates TREM2 signaling in HEK293-hTREM2/DAP12 cells. TREM2 agonist-5 displays a superior in vitro pharmacokinetic profile to VG-3927. TREM2 agonist-5 can used for the study of Alzheimers disease[1].
Molekulargewicht:
449.91
Reinheit:
99.75
Formel:
C24H21ClFN5O
Target-Kategorie:
TREM receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound
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