M4 mAChR Modulator-2, CAS [[3062458-27-6]] Preis auf Anfrage

Produktübersicht

• Artikelname: M4 mAChR Modulator-2, CAS [[3062458-27-6]] Preis auf Anfrage
• Artikelnummer: MCE-HY-175532
• Hersteller Artikelnummer: HY-175532
• Alternativnummer: MCE-HY-175532-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

M4 mAChR Modulator-2 is an orally active, selective, brain-penetrant positive allosteric modulator (PAM) of the M4 muscarinic acetylcholine receptor (M4 mAChR) (EC50 = 513 nM). M4 mAChR Modulator-2 exhibits high target selectivity, showing negligible affinity and low inhibition rates for non-target receptors (D1R/D2R/D3R, 5-HT subtypes, kappa/delta/µ opioid receptors, H1, M1/M2) while specifically binding to M4 mAChR with a Ki of 377 nM and an inhibition rate of 62.8%. M4 mAChR Modulator-2 reverses Dizocilpine (MK-801) (HY-15084B)-induced hyperlocomotion in mice. M4 mAChR Modulator-2 can be used for the study of schizophrenia[1]

Produkteigenschaften

• Molekulargewicht: 441.50
• CAS Nummer: [3062458-27-6]
• Formel: C26H24FN5O
• Target-Kategorie: mAChR

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound1