PROTAC HPK1 Degrader-5, CAS [[3108744-13-1]] Preis auf Anfrage

Produktübersicht

• Artikelname: PROTAC HPK1 Degrader-5, CAS [[3108744-13-1]] Preis auf Anfrage
• Artikelnummer: MCE-HY-175547
• Hersteller Artikelnummer: HY-175547
• Alternativnummer: MCE-HY-175547-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

PROTAC HPK1 Degrader-5 is a potent and orally active HPK1 PROTAC degrader (DC50 = 5.0 nM, Dmax 99%). PROTAC HPK1 Degrader-5 significantly inhibits SLP76 phosphorylation and enhanced ERK pathway activation through degrading HPK1, thereby stimulating IL-2 and IFN-gamma release. PROTAC HPK1 Degrader-5 exhibits the ability to overcome the immunosuppressive effects imposed by PGE2, NECA or TGF-beta. PROTAC HPK1 Degrader-5 alone efficaciously inhibits tumor growth in an MC38 syngeneic mouse model. PROTAC HPK1 Degrader-5 can be used for the study of tumor (such as colorectal cancer) immunotherapy (Pink: Target protein ligand (HY-175549), Blue: E3 ligand (HY-W023573), Black: Linker, E3 ligand + Linker (HY-175551))[1].

Produkteigenschaften

• Molekulargewicht: 795.89
• CAS Nummer: [3108744-13-1]
• Formel: C43H45N11O5
• Target-Kategorie: ERK,IFNAR,Interleukin Related,MAP4K,PROTACs

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound