DPP-4-IN-17 is an orally active and selective dipeptidyl peptidase-4 (DPP-4) inhibitor with an IC50 value of 0.12 nM. DPP-4-IN-17 increases the enzymes Km value (75.73 µM vs. 27.18 µM of substrate alone) and reduces catalytic efficiency. DPP-4-IN-17 reduces blood glucose levels and reverses weight loss in Streptozotocin (STZ) (HY-13753)/Nicotinamide (NA) (HY-B0150)-induced diabetic rats. DPP-4-IN-17 can be used for the study of type 2 diabetes mellitus (T2DM)[1].
Molekulargewicht:
651.79
Formel:
C32H53N5O9
Target-Kategorie:
Dipeptidyl Peptidase
Anwendungsbeschreibung:
MCE Product type: Reference compound
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