PROTAC FLT3/JAK2/BRD4 Degrader-1, CAS [[3067695-20-6]] Preis auf Anfrage

Produktübersicht

• Artikelname: PROTAC FLT3/JAK2/BRD4 Degrader-1, CAS [[3067695-20-6]] Preis auf Anfrage
• Artikelnummer: MCE-HY-175610
• Hersteller Artikelnummer: HY-175610
• Alternativnummer: MCE-HY-175610-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

PROTAC FLT3/JAK2/BRD4 Degrader-1 is a PROTAC degrader that target FLT3, JAK2, and BRD4 with DC50 values of 5.23, 0.678, and 1.17 nM, respectively. PROTAC FLT3/JAK2/BRD4 Degrader-1 exhibits potent antiproliferative activity against MV4,11 cells (IC50 = 0.79 nM) and FLT3 mutant-transformed Ba/F3 cells. PROTAC FLT3/JAK2/BRD4 Degrader-1 induces apoptosis in MV4,11 cells. PROTAC FLT3/JAK2/BRD4 Degrader-1 demonstrates significant anti-tumor efficacy in the MV4,11 xenograft model established in NOD SCID mice. PROTAC FLT3/JAK2/BRD4 Degrader-1 can be used for the study of acute myeloid leukemia (AML). (Pink: FLT3/JAK2/BRD4 ligand (HY-175611), Blue: CRBN Ligand (HY-W087383), Black: Linker, E3 ligase ligand-linker conjugate (HY-W897939))[1].

Produkteigenschaften

• Molekulargewicht: 883.00
• CAS Nummer: [3067695-20-6]
• Formel: C44H51FN10O7S
• Target-Kategorie: Epigenetic Reader Domain,FLT3,JAK,PROTACs

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound