P2Y1 antagonist 4 is a selective P2Y1 receptor antagonist with excellent blood-brain barrier (BBB) penetration. P2Y1 antagonist 4 inhibits P2Y1 receptor-mediated cytosolic Ca2+ increase (IC50 = 1.95 µM) and platelet aggregation (IC50 = 3.24 µM) induced by ADP in rabbit washed platelets. P2Y1 antagonist 4 significantly upregulates the level of nuclear Nrf2 protein in H2O2-treated HT22 cells. P2Y1 antagonist 4 reduces myocardial infarct size in a mouse acute myocardial infarction (MI) model. P2Y1 antagonist 4 can be used for the study of ischemic stroke and myocardial infarction[1].
Molekulargewicht:
446.33
Formel:
C21H11F5N4O2
Target-Kategorie:
Keap1-Nrf2,P2Y Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound
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