MBL-IN-6 (Compound 6d) is a Metallo-beta-lactamase (MBL) inhibitor with Kis of 2.6 and 0.08 µM for NDM-1 and VIM-2, respectively. MBL-IN-6 has a synergistic activities with Imipenem (HY-B1369A) on MBL-producing clinical isolates (such as E. coli SI-M001, K. pneumonia T2301 and S. marcescens SI-1591) with MICs of 2-64 µg/mL. MBL-IN-6 does not have off-target effects without ACE-1 inhibition activity. MBL-IN-6 can be used for antimicrobial resistance research[1].
Molekulargewicht:
320.45
Formel:
C17H24N2O2S
Target-Kategorie:
Bacterial,Beta-lactamase
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
