mIDH1-IN-2 Preis auf Anfrage

Produktübersicht

• Artikelname: mIDH1-IN-2 Preis auf Anfrage
• Artikelnummer: MCE-HY-175770
• Hersteller Artikelnummer: HY-175770
• Alternativnummer: MCE-HY-175770-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

mIDH1-IN-2 is a brain-penetrant isocitrate dehydrogenase 1 (IDH1) inhibitor. mIDH1-IN-2 shows subnanomolar potency against IDH1 R132H and R132C (IC50 = 80.0 and 58.0 nM) and minimal activity against wt-IDH1/2. mIDH1-IN-2 also inhibits PDK1 (IC50 = 0.61 µM) and reduces PDH phosphorylation dose-dependently. mIDH1-IN-2 can inhibit cells proliferation, induces S phase arrest and promotes apoptosis. mIDH1-IN-2 can be used for the research of cancer, such as glioma[1].

Produkteigenschaften

• Molekulargewicht: 501.19
• Formel: C18H15Br2NO4S
• Target-Kategorie: Apoptosis,Isocitrate Dehydrogenase (IDH),PDK-1

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound