SARM1-IN-7 is a potent active site (orthosteric) and orally active SARM1 inhibitor. SARM1-IN-7 continuously activates the enzymatic activity of SARM1, thereby exacerbating the depletion of NAD at sub-minimal concentrations. SARM1-IN-7 demonstrated dual benefits in the SARM1-activated cell models and mouse models: a high dose exerted a cell/neuron protective effect, while a low dose exacerbated cell/neuron damage. SARM1-IN-7 can be used for the study of axon degeneration[1].
Molekulargewicht:
247.22
Formel:
C10H12F3N3O
Target-Kategorie:
Toll-like Receptor (TLR)
Anwendungsbeschreibung:
MCE Product type: Reference compound
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