BWA-6047 is a dual AR/AR-V7 and GSPT1 PROTAC degrader (AR: DC50 = 3.7 nM, AR-V7: DC50 = 3.0 nM, GSPT1: DC50 = 1.2 nM). BWA-6047 promotes ubiquitination and degradation of AR/AR-V7 and, through its molecular glue properties, induces the formation of a PPI between GSPT1 and CRBN, leading to GSPT1 degradation. BWA-6047 can be used in prostate cancer research (Pink: AR/AR-V7 ligand (HY-176129), Blue: E3 CRBN ligand (HY-W069604), Black: linker (HY-W069604))[1].
Molekulargewicht:
768.30
Formel:
C42H46ClN5O7
Target-Kategorie:
Androgen Receptor,Molecular Glues,PROTACs
Anwendungsbeschreibung:
MCE Product type: Reference compound1
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
