Tegoprazan (CJ-12420), a potassium-competitive acid blocker, is a reversible, orally active and highly selective inhibitor of gastric H+/K+-ATPase. Tegoprazan inhibits gastric acid secretion and motility against porcine, canine and human H+/K+-ATPase with IC50 values ranging from 0.29-0.52 µM in vitro. Tegoprazan significantly improves colitis and enhances the intestinal epithelial barrier function in mice. Tegoprazan is promising for research of Inflammatory bowel, gastric acid-related, motilityimpaired diseases[1][2][3].
Molekulargewicht:
387.38
Reinheit:
99.76
CAS Nummer:
[942195-55-3]
Formel:
C20H19F2N3O3
Target-Kategorie:
Na+/K+ ATPase,Potassium Channel,Proton Pump
Anwendungsbeschreibung:
MCE Product type: Reference compound1
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