PROTAC PI3Kdelta degrader-1 Preis auf Anfrage
Artikelnummer:
MCE-HY-176239
| Artikelname: |
PROTAC PI3Kdelta degrader-1 Preis auf Anfrage |
| Artikelnummer: |
MCE-HY-176239 |
| Hersteller Artikelnummer: |
HY-176239 |
| Alternativnummer: |
MCE-HY-176239-1UNIT |
| Hersteller: |
MedchemExpress |
| Kategorie: |
Biochemikalien |
| PROTAC PI3Kdelta degrader-1 is a Lysine-targeted covalent PI3Kdelta PROTAC degrader with a DC50 of 3.98 nM. PROTAC PI3Kdelta degrader-1 has a potent antiproliferative activity and selective PI3Kdelta inhibition (IC50: 8 nM). PROTAC PI3Kdelta degrader-1 also significantly degrades p-AKT, induces cell cycle arrest in G1 phase and prompts cell apoptosis and autophagy. PROTAC PI3Kdelta degrader-1 effectively inhibits the tumor growth in SU-DHL-6 xenograft mice model[1]. Pink: PI3Kdelta ligand (HY-169983), Blue: VHL ligase ligand (HY-112078), Black: linker (HY-W013381) |
| Molekulargewicht: |
1150.44 |
| Formel: |
C63H79N11O8S |
| Target-Kategorie: |
Akt,Apoptosis,Autophagy,PI3K,PROTACs |
| Anwendungsbeschreibung: |
MCE Product type: Reference compound1 |
