S1PR5-IN-1 (Compound 7a) is a selective and BBB-penetrable S1PR5 inhibitor with an IC50 of 85.4 nM. S1PR5-IN-1 has a superior binding capacity on S1PR5 with Kds of 2.2, 4.6, and 27.6 nM for recombinant human S1PR5 cell membranes, C57BL/6 mouse brain, and human cerebral cortex, respectively. S1PR5-IN-1 can be used for neurodegenerative disorders like multiple sclerosis research[1].
Molekulargewicht:
441.58
CAS Nummer:
[3107268-28-7]
Formel:
C27H36FNO3
Target-Kategorie:
LPL Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound
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