KB-0118, CAS [[2648377-08-4]] Preis auf Anfrage

Produktübersicht

• Artikelname: KB-0118, CAS [[2648377-08-4]] Preis auf Anfrage
• Artikelnummer: MCE-HY-176535
• Hersteller Artikelnummer: HY-176535
• Alternativnummer: MCE-HY-176535-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien
• Alternative Synonym: BBC0115

Produktbeschreibung

KB-0118 (BBC0115) is an orally active BET bromodomain inhibitor. KB-0118 selective binds to BRD2 and BRD4 over BRD3, with Kd values of 36.7 µM for BRD2 BD1 and 47.4 µM for BRD4 BD1. KB-0118 inhibits pro-inflammatory cytokines, including TNF, IL-1beta, and IL-23a and selectively suppresses Th17 cell differentiation. KB-0118 modulates Th17-driven inflammation occurs through epigenetic suppression of BRD4, confirmed by downregulation of STAT3 and BRD4 target genes. KB-0118 has immunomodulatory effects in inflammatory bowel disease (IBD) model[1].

Produkteigenschaften

• Molekulargewicht: 309.27
• CAS Nummer: [2648377-08-4]
• Formel: C17H11NO5
• Target-Kategorie: Epigenetic Reader Domain,Interleukin Related,STAT

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound