PAD-PF2 is a PAD family inhibitor, as well as a kappa-opioid receptor agonist (EC50 = 7.55 µM) and an M1 muscarinic acetylcholine receptor antagonist (IC50 = 12.3 µM). The IC50 values of PAD-PF2 against PAD1, PAD2, PAD3 and PAD4 are 109 nM, 27.9 nM, 106 nM and 20.1 nM, respectively. PAD-PF2 binds to the common allosteric pocket of PAD1-4, and its inhibitory effects on PAD2 and PAD4 are Ca2+-dependent. PAD-PF2 inhibits protein citrullination in neutrophils. PAD-PF2 is applicable to research related to rheumatoid arthritis, neurodegenerative diseases and cancer[1].
Molekulargewicht:
484.42
Reinheit:
99.94
Formel:
C25H27Cl2N5O
Target-Kategorie:
mAChR,Opioid Receptor,Protein Arginine Deiminase
Anwendungsbeschreibung:
MCE Product type: Reference compound
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