CZL-S092 is a PLK4 inhibitor with an IC50 value of 0.9 nM and excellent selectivity over other PLK4 family members (PLK1, PLK2, and PLK3). CZL-S092 exhibits anti-neuroblastoma activity in vitro (IMR-32 cells, IC50 = 1.143 µM). CZL-S092 inhibits cell migration and halts the cell cycle and induces apoptosis. CZL-S092 can be used in studies of various cancers including neuroblastoma cancer[1].
Molekulargewicht:
418.49
Formel:
C23H19FN4OS
Target-Kategorie:
Polo-like Kinase (PLK)
Anwendungsbeschreibung:
MCE Product type: Reference compound
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