GNE-5152 is an orthosteric SARM1 base-exchange (BE) inhibitor. GNE-5152 sustainably activates SARM1 at subinhibitory concentrations under mildly activating conditions, and this synergistic adverse effect increases NAD consumption, induces axon degradation and neurodegeneration and releases neurofilament-light (NfL) in cortical neurons. GNE-5152 can be used for neurodegenerative diseases research[1].
Molekulargewicht:
365.38
CAS Nummer:
[3080315-83-6]
Formel:
C21H17F2N3O
Target-Kategorie:
Toll-like Receptor (TLR)
Anwendungsbeschreibung:
MCE Product type: Reference compound
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