PROTAC SGK3 degrader-2, CAS [[2381196-78-5]] Preis auf Anfrage

Produktübersicht

• Artikelname: PROTAC SGK3 degrader-2, CAS [[2381196-78-5]] Preis auf Anfrage
• Artikelnummer: MCE-HY-176823
• Hersteller Artikelnummer: HY-176823
• Alternativnummer: MCE-HY-176823-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

PROTAC SGK3 degrader-2 is the cis epimer of PROTAC SGK3 degrader-1 (SGK3-PROTAC1) (HY-125878), with a cis hydroxyl group in its VH032 moiety, which is incapable of binding to the VHL E3 ligase. PROTAC SGK3 degrader-2 exhibits inhibitory activity against SGK3, SGK1, and S6K1 with IC50 values of 0.6 µM, 1.4 µM, and 1.7 µM, respectively, but shows no SGK3 degradation efficiency. PROTAC SGK3 degrader-2 can be used as a control compound to study the specific effects of SGK3-PROTAC1-mediated SGK3 degradation. (Pink: SGK3 ligand (HY-167701), Blue: VHL Ligand (HY-120217A), Black: Linker (HY-130618), SGK3 ligand-linker conjugate (HY-176824))[1].

Produkteigenschaften

• Molekulargewicht: 1157.38
• CAS Nummer: [2381196-78-5]
• Formel: C57H73FN10O11S2
• Target-Kategorie: PROTACs,SGK

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound