NEK7 degrader-1 (Compound 17) is a NEK7 degrader with a DC50 of 0.1 nM. NEK7 degrader-1 dose-dependently inhibits caspase-1 activity and IL-beta release in macrophages in response to NLRP3 inflammasome activation. NEK7 degrader-1 can be used for autoinflammatory and autoimmune disorders like multiple sclerosis, neurodegeneraive diseases like Alzheimers disease and cardiovascular and melabolic disorders like pericarditis and Type 2 diabetes research[1].