AXT-914 is a negative allosteric modulator/antagonist of the mutated calcium-sensing receptor (CaSR). AXT-914 reduces the sensitivity of the receptor to extracellular calcium, corrects the hyperresponsive state, inhibits extracellular calcium-induced intracellular calcium mobilization, and attenuates excessive cytoplasmic calcium signaling. AXT-914 can be used in the research of autosomal dominant hypocalcemia and type 5 Bartter syndrome[1][2].
Molekulargewicht:
487.39
Reinheit:
98.83
CAS Nummer:
[717104-43-3]
Formel:
C27H23BrN2O2
Target-Kategorie:
CaSR
Anwendungsbeschreibung:
MCE Product type: Reference compound
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