KB05yne is a site-selective, alkyne-functionalized electrophilic scout fragment probe designed for covalent ligand discovery, with preferential reactivity toward specific cysteine residues in proteins. KB05yne strongly labels wild-type forms of target proteins (e.g., CDKN2AIP, HPCAL1) but not their cysteine-to-alanine mutants, confirming site-specific cysteine reactivity. KB05yne can be used for site-specific covalent ligand discovery and optimization for structurally and functionally diverse proteins, particularly in studies targeting cysteine residues in cancer-related or difficult-to-purify proteins[1].
Molekulargewicht:
425.32
Reinheit:
98.78
CAS Nummer:
[2724919-69-9]
Formel:
C22H21BrN2O2
Target-Kategorie:
Biochemical Assay Reagents
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
