AMPA receptor modulator-10 (Compound 9a) is an orally active AMPA receptor (AMPAR) positive allosteric modulator. AMPA receptor modulator-10 exhibits potent activity (pEC50 = 5.0) on the GluA2 subtype of AMPAR, significantly enhancing glutamate-induced calcium influx and current responses. AMPA receptor modulator-10 can reverse the memory impairment induced by Scopolamine (HY-N0296) and enhance cognitive function. AMPA receptor modulator-10 can be used for the research of neurological disease, such as schizophrenia[1].
Molekulargewicht:
363.38
Reinheit:
98.78
CAS Nummer:
[620940-01-4]
Formel:
C19H20F3N3O
Target-Kategorie:
iGluR
Anwendungsbeschreibung:
MCE Product type: Reference compound
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