MRS4917 is an orally active, potent selective P2Y14 receptor (hP2Y14R) antagonist (IC50 = 2.88 nM, Ki = 1.67 nM) that shows >18,000 fold selectivity against P2Y6R (IC50 = 54 µM). MRS4917 demonstrates oral efficacy in reversing established mechanoallodynia in the chronic constriction injury (CCI) mouse model, while having no effect on thermoregulation. MRS4917 can be used for neurological diseases research[1].
Molekulargewicht:
458.43
Formel:
C27H17F3N2O2
Target-Kategorie:
P2Y Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound
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