SIK1-IN-1 (Compound 27) is a selective Salt-inducible kinase 1 (SIK1) inhibitor with an IC50 of 0.7 nM for SIK1 over SIK2 and SIK3. SIK1-IN-1 has no cytotoxicity against HEK293 cells and PBMCs (maximum concentration of 30 µM). SIK1-IN-1 also has potent inhibitory activities for 392 kinases, in particular tyrosine kinases, such as FGR, HCK and LYN)[1].
Molekulargewicht:
409.87
Formel:
C21H20ClN5O2
Target-Kategorie:
Salt-inducible Kinase (SIK),Src
Anwendungsbeschreibung:
MCE Product type: Reference compound
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