PROTAC G9a/GLP degrader 1 is a G9a/GLP PROTAC degrader with DC50s of 336 nM (G9a) and 988 nM (GLP). PROTAC G9a/GLP degrader 1 exhibits inhibitory activity against G9a with an IC50 of 98 nM. PROTAC G9a/GLP degrader 1 effectively inhibits the migration of breast cancer MCF-7 cells without inhibiting cell proliferation. PROTAC G9a/GLP degrader 1 can be used for the study of breast cancer (Pink: G9a/GLP ligand (HY-152775), Blue: VHL ligand (HY-125845), Black: Linker (HY-140468))[1].
Molekulargewicht:
1081.33
Formel:
C57H76N8O11S
Target-Kategorie:
GLP Receptor,Histone Methyltransferase,PROTACs
Anwendungsbeschreibung:
MCE Product type: Reference compound
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