D1R antagonist 2 (Compound 13a) is a BBB-penetrable D1R antagonist with IC50s of 35.6 and 70 nM for cAMP-based D1R and beta-arrestin-based D1R, respectively. D1R antagonist 2 effectively antagonizes D1R-mediated cAMP and beta-arrestin recruitment. D1R antagonist 2 can be used for neurodegenerative and neuropsychiatric diseases such as schizophrenia, Parkinsons disease and Alzheimers disease research[1].
Molekulargewicht:
470.30
Formel:
C21H22BrF2NO4
Target-Kategorie:
Arrestin,Dopamine Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound
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