Lck-IN-4 (Compound A-1) is a protein tyrosine kinase Lck inhibitor with an IC50 of 2 nM. Lck-IN-4 significantly inhibits YAP tyrosine phosphorylation and activity and induces apoptosis in cholangiocarcinoma CCA cells. Lck-IN-4 is cytotoxic in CCA tumor-derived organoids with elevated YAP activity Lck-IN-4 can be used for cancers like cholangiocarcinoma (CCA) research[1].
Molekulargewicht:
621.77
CAS Nummer:
[1326278-38-9]
Formel:
C36H43N7O3
Target-Kategorie:
Apoptosis,Src
Anwendungsbeschreibung:
MCE Product type: Reference compound
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