HDAC degrader-2 is a selective HDAC degrader with a DC50 values of 2.55 µM against HDAC1. HDAC degrader-2 effectively induces the degradation of HDAC1 and HDAC2, but has no significant effect on the degradation of HDAC3, 4, 6 and 8. HDAC degrader-2 exerts potent antiproliferative effects against MM.1S and MCF-7 cells. HDAC degrader-2 induces apoptosis in myeloma cells. HDAC degrader-2 can be used for the study of myeloma[1].
Molekulargewicht:
591.10
Formel:
C32H35ClN4O5
Target-Kategorie:
Apoptosis,HDAC
Anwendungsbeschreibung:
MCE Product type: Reference compound
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