PI3KC2gamma-IN-1 (Compound 23) is an orally active and selective PI3KC2gamma inhibitor (IC50 = 4 nM). PI3KC2gamma-IN-1 downregulats the Akt2-glycogen synthase (GS) signaling pathway, ultimately inhibiting the conversion of glucose to glycogen and reduces excessive glycogen accumulation in the liver. PI3KC2gamma-IN-1 can significantly inhibit insulin-induced PI(3,4)P2 accumulation in both primary hepatocytes and HepG2 liver cancer cells. PI3KC2gamma-IN-1 can be used for the study of glycogen storage diseases (GSDs)[1].
Molekulargewicht:
402.43
Formel:
C20H14N6O2S
Target-Kategorie:
PI3K
Anwendungsbeschreibung:
MCE Product type: Reference compound
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