Nav1.7-IN-19 is a potent, selective and orally active Nav1.7 inhibitor with an IC50 of 0.49 µM. Nav1.7-IN-19 shows high selectivity for Nav1.7, with selectivities of 312-fold and 662-fold against Nav1.1 and Nav1.5 in the inactivated state. Nav1.7-IN-19 exhibits weak inhibition on hERG potassium channels. Nav1.7-IN-19 exhibits analgesic effect and can be used for the research of neurological disease[1].
Molekulargewicht:
601.87
Reinheit:
98.87
CAS Nummer:
[3097995-73-5]
Formel:
C23H23BrClFN4O5S
Target-Kategorie:
Potassium Channel,Sodium Channel
Anwendungsbeschreibung:
MCE Product type: Reference compound
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