LD-110 is a highly efficient and effective PROTAC degrader targeting LSD1 (DC50 = 0.44 µM). LD-110 promotes LSD1 degradation and increases the level of H3K4 dimethylation in a ubiquitin-proteasome-dependent manner. LD-110 inhibits the growth and survival of multiple esophagus squamous cancer cell (ESCC) lines by inducing apoptosis. LD-110 can be used for the study of esophagus squamous cancer. Red: LSD1 ligand (HY-178826), Blue: E3 ligase CRBN ligand (HY-14658), Black: Linker (HY-N2578)[1].
Molekulargewicht:
739.82
Formel:
C42H41N7O6
Target-Kategorie:
Apoptosis,Histone Demethylase,PROTACs
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
