PDE2-IN-1 is a potent and orally active PDE2 inhibitor with an IC50 of 0.6 µM, demonstrating neuroprotective effects. PDE2-IN-1 modulates the PKA/CREB/BDNF signaling pathway by inhibiting PDE2. PDE2-IN-1 improves memory deficits and cognitive impairment in an okadai acid (OKA)-induced Alzheimers disease (AD) mouse model. PDE2-IN-1 can be used for the research of AD[1].
Molekulargewicht:
396.36
Formel:
C18H19F3N4O3
Target-Kategorie:
Phosphodiesterase (PDE),PKA
Anwendungsbeschreibung:
MCE Product type: Reference compound
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