HPK1-IN-65 is a selective and orally active HPK1 inhibitor with an IC50 value of HPK1 kinase activity and displays 1257-fold selectivity over the MAP4K kinase family member GLK. HPK1-IN-65 exhibits an IC50 of 92.3 nM for inhibiting pSLP76 phosphorylation. HPK1-IN-65 demonstrates an EC50 of 398 nM for stimulating IL-2 production. HPK1-IN-65 inhibits TCR-induced phosphorylation of SLP76 at Ser376 in a dose-dependent manner. HPK1-IN-65 can be further utilized for colorectal cancer research[1].
Molekulargewicht:
528.99
Formel:
C23H22ClFN8O2S
Target-Kategorie:
HOXA,Interleukin Related,MAP4K
Anwendungsbeschreibung:
MCE Product type: Reference compound
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