EL244 is a dua Autotaxin (ATX) (IC50 = 50 nM) inhibitor and PPARgamma (IC50 = 1.3 µM, Kd = 1.3 µM) agonist. EL244 demonstrates low cytotoxicity in human HepG2 cells (EC50 = 81.2 µM) with minimal inhibition of the cardiac hERG potassium channel (12% at 25 µM). EL244 significantly reduces pulmonary Lysophosphatidic Acid (LPA) levels, attenuates fibrosis, and restores respiratory function with limited systemic absorption in vivo. EL244 can be used for idiopathic pulmonary fibrosis and interstitial lung disease (ILD) research[1].
Molekulargewicht:
537.46
Reinheit:
99.55
CAS Nummer:
[3047548-70-6]
Formel:
C25H26Cl2N2O5S
Target-Kategorie:
Phosphodiesterase (PDE),PPAR
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
