GSTO1-IN-6 is an allosteric and covalent GSTO1 inhibitor with an IC50 of 457 nM. GSTO1-IN-6 markedly reduces Lipopolysaccharides (LPS) (HY-D1056)-induced IL-1beta (IC50 of 1.9 µM) and IL-18 (IC50 of 10. µM) secretion in human monocyte-derived macrophages. GSTO1-IN-6 covalently modifies GSTO1-Cys32, inducing conformational changes and protein destabilization. GSTO1-IN-6 can be used for the research of inflammatory diseases[1].
Molekulargewicht:
353.36
Formel:
C16H14F3N3OS
Target-Kategorie:
Glutathione S-transferase,Interleukin Related
Anwendungsbeschreibung:
MCE Product type: Reference compound
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