PZ-1657 Preis auf Anfrage
Artikelnummer:
MCE-HY-179724
| Artikelname: |
PZ-1657 Preis auf Anfrage |
| Artikelnummer: |
MCE-HY-179724 |
| Hersteller Artikelnummer: |
HY-179724 |
| Alternativnummer: |
MCE-HY-179724-1UNIT |
| Hersteller: |
MedchemExpress |
| Kategorie: |
Biochemikalien |
| PZ-1657 (Compound 57) is an orally active, blood-brain barrier permeable, highly selective, and metabolically stable 5-HT7 receptor inverse agonist with a Ki value of 5 nM. PZ-1657 inhibits constitutive cyclic adenosine monophosphate (cAMP) production mediated by the Gs signaling pathway (EC50 value of 2.93 nM). PZ-1657 inhibits CYP3A4 P450 (IC50 = 12.2 µM) and hERG channels. PZ-1657 reduces 5-HT7 receptor-mediated MMP-9 activity. PZ-1657 reverses Phencyclidine-induced cognitive impairment. PZ-1657 possesses antidepressant properties[1]. |
| Molekulargewicht: |
458.55 |
| Formel: |
C23H27FN4O3S |
| Target-Kategorie: |
5-HT Receptor,Cytochrome P450,Dopamine Receptor,MMP |
| Anwendungsbeschreibung: |
MCE Product type: Reference compound |
