SH543 is a potent anti-osteoporosis agent. SH543 inhibits nuclear factor kappaB ligand (RANKL)-induced osteoclastogenesis with an IC50 of 3.3 nM. SH543 directly binds to KEAP1, activates the Nrf2-HO-1 antioxidant pathway, reduces ROS levels, and inhibits PI3K-AKT and MAPK signaling pathways. SH543 attenuates pathological bone loss in ovariectomized mice. SH543 can be used for osteoporosis research[1].
Molekulargewicht:
543.82
Formel:
C37H53NO2
Target-Kategorie:
Akt,Keap1-Nrf2,p38 MAPK,PI3K,Reactive Oxygen Species (ROS)
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
