VU6052254, a derivative of VU0467319 (HY-173396), is a selective, potent, orally active and brain-penetrant muscarinic M1 acetylcholine receptor (mAChR1) positive allosteric modulator with an EC50 of 59 nM. VU6052254 has no activity on the M2-5 receptor (EC50 > 30 µM). VU6052254 can improve memory recognition ability and reverse the cognitive impairment induced by Scopolamine (HY-N0296) with minimum effective dose both of 1 mg/kg. VU6052254 can be used for the research of neurological disease, such as Alzheimers disease[1].
Molekulargewicht:
448.46
CAS Nummer:
[3035701-02-8]
Formel:
C25H22F2N4O2
Target-Kategorie:
Drug Derivative,mAChR
Anwendungsbeschreibung:
MCE Product type: Reference compound
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