SERCA2a activator 2 (Compound 25) is a potent SERCA2a (cardiac type) activator, which also has an activating effect on SERCA1a (skeletal muscle type). SERCA2a activator 2, under [Ca]MAX conditions activates the ATPase activity of SERCA2a and promotes Ca uptake, with its EC50 values being 4 µM and 0.80 µM respectively. SERCA2a activator 2 also exhibits consistent activating effects under more physiological [Ca]MID conditions. SERCA2a activator 2 has low cytotoxicity and can be used for research on diseases such as heart failure[1].
Molekulargewicht:
380.25
Formel:
C18H19BrFNO2
Target-Kategorie:
Calcium Channel
Anwendungsbeschreibung:
MCE Product type: Reference compound
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