PAM-2 is a potent, orally active, CNS-penetrant selective alpha7 nAChR positive allosteric modulator (human alpha7 nAChR EC50: 39 µM, rat alpha7 nAChR EC50: 12 µM) with anti-nociceptive and anti-inflammatory activity. PAM-2 exhibits selectivity over alpha9alpha10 nAChR (IC50 = 174 µM) and CaV2.2 channel (IC50 = 89 µM). PAM-2 decreases Streptozotocin (STZ) (HY-13753)- and Oxaliplatin (HY-17371)-inducned nuroparhic pain in mice by alpha7 nAChR potentiation. PAM-2 can be used for the research of neuropathic pain[1].
Molekulargewicht:
227.26
CAS Nummer:
[1426293-61-9]
Formel:
C14H13NO2
Target-Kategorie:
Calcium Channel,nAChR
Anwendungsbeschreibung:
MCE Product type: Reference compound
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