ML252 is a selective inhibitor of KCNQ2 (Kv7.2) channel with an IC50s of 69 nM, 2.92 µM, 0.12 µM and 0.20 µM for KCNQ2, KCNQ1 (Kv7.1), KCNQ2/Q3 and KCNQ4, respectively. ML252 also inhibits Cytochrome P450 with IC50s of 6.1 nM (CYP1A2), 18.9 nM (CYP2C9), 3.9 nM (CYP3A4), 19.9 nM (CYP2D6), respectively. ML252 shows highly brain penetrant [1][2].
Molekulargewicht:
308.42
Reinheit:
99.9
CAS Nummer:
[1392494-64-2]
Formel:
C20H24N2O
Target-Kategorie:
Cytochrome P450,Potassium Channel
Anwendungsbeschreibung:
MCE Product type: Reference compound
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