NLRP3-IN-86, CAS [[2361570-54-7]] Preis auf Anfrage
Artikelnummer:
MCE-HY-180830
Hersteller Artikelnummer:
HY-180830
Alternativnummer:
MCE-HY-180830-1UNIT
Hersteller:
MedchemExpress
Kategorie:
Biochemikalien
NLRP3-IN-86 (Compound 8a), a derivative of Songorine (HY-N2080), is a potent and selective NLRP3 inflammasome inhibitor. NLRP3-IN-86 can reduce LPS (HY-D1056)- and Nigericin (HY-127019)-stimulated lactate dehydrogenase (LDH) release (IC50 = 2.69 µM in THP-1 cells and 1.75 µ M in J774A.1 cells). NLRP3-IN-86 can inhibit gasdermin D (GSDMD) cleavage and IL-1beta secretion. NLRP3-IN-86 can inhibit cell pyroptosis. NLRP3-IN-86 can be used for research of inflammation[1].
