DIX-01 is a molecular gel degrader that can simultaneously induce the degradation of IKZF1/3 and GSPT1 mediated by CRBN. Its DC50 values are: IKZF1 (19.80 nM), IKZF3 (45.31 nM), and GSPT1 (120.1 nM). DIX-01 exhibits nanomolar-level potent anti-proliferative activity in various cancer cell lines. DIX-01 induces apoptosis in MV4-11 cells and significantly inhibits the growth of leukemia cells in zebrafish. DIX-01 can be used for the study of malignant hematological tumors[1].
Molekulargewicht:
538.59
Formel:
C31H30N4O5
Target-Kategorie:
Apoptosis,IKZF Family,Molecular Glues
Anwendungsbeschreibung:
MCE Product type: Reference compound
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