QO-83, Retigabine analogue, is a voltage-gated potassium channel KCNQ2 (Kv7.2) activator with an EC50 of 0.56 µM. QO-83 binds to a single hydrophobic pocket of KCNQ2-CaM complex in closed conformation. QO-83 induces a negative shift in the voltage-dependent activation curve of KCNQ2 channels, increasing the channels voltage sensitivity. QO-83 can be used for the research of epilepsies[1].
Molekulargewicht:
423.45
CAS Nummer:
[2253948-15-9]
Formel:
C22H25F4N3O
Target-Kategorie:
Potassium Channel
Anwendungsbeschreibung:
MCE Product type: Reference compound
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