SR-5037, CAS [[2387704-74-5]]

Produktübersicht

• Artikelname: SR-5037, CAS [[2387704-74-5]]
• Artikelnummer: MCE-HY-181405
• Hersteller Artikelnummer: HY-181405
• Alternativnummer: MCE-HY-181405-25MG,MCE-HY-181405-50MG,MCE-HY-181405-10MG,MCE-HY-181405-5MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

SR-5037 is an orally active CDK12 (IC50 = 31 nM)/CDK13 inhibitor and CycK (DC50 = 30 nM,Dmax > 98%) molecular glue degrader. SR-5037 inhibits the enzymatic activity of CDK12/CycK and CDK13/CycK complexes. SR-5037 promotes the recruitment of DDB1 to the CDK12/CycK complex, thereby triggering proteasome-mediated CycK degradation. SR-5037 degrades active CycK in mouse models of triple-negative breast cancer. SR-5037 can be used in the research of cancers such as triple-negative breast cancer[1].

Produkteigenschaften

• Molekulargewicht: 535.34
• CAS Nummer: [2387704-74-5]
• Formel: C21H18Cl2F2N10O
• Target-Kategorie: CDK,Molecular Glues

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound