PARP1 degrader-2 (Compound 11e) is a potent, selective PARP1 HYT degrader (DC50: 2.16 µM). PARP1 degrader-2 selectively binds to and degrades PARP1 but not PARP2. PARP1 degrader-2 mediates the degradation of PARP1 via the ubiquitin-proteasome system (UPS). PARP1 degrader-2 exhibits anticancer activity against triple-negative breast cancer and colon cancer (hydrophobic tag: (HY-W022007), PARP1 ligand: (HY-75706), Linker: (HY-W015300))[1].
Molekulargewicht:
627.75
Formel:
C36H42FN5O4
Target-Kategorie:
HyT,PARP
Anwendungsbeschreibung:
MCE Product type: Reference compound
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