NLRP3-IN-87, CAS [[3097745-69-9]] Preis auf Anfrage
Artikelnummer:
MCE-HY-181488
Hersteller Artikelnummer:
HY-181488
Alternativnummer:
MCE-HY-181488-1UNIT
Hersteller:
MedchemExpress
Kategorie:
Biochemikalien
NLRP3-IN-87 is a selective and orally active NLRP3 inhibitor with a Kd of 0.23 µM. NLRP3-IN-87 binds directly to the NLRP3 NACHT domain, disrupts NLRP3-NEK7 and NLRP3-ASC interactions, inhibits ASC oligomerization, and blocks inflammasome assembly. NLRP3-IN-87 suppresses caspase-1 activation and IL-1beta secretion. NLRP3-IN-87 exhibits anti-inflammatory and analgesic activity, reducing joint swelling, inflammation, and pain in an MSU (HY-B2130A)-induced acute gout mouse model. NLRP3-IN-87 can be used for the research of gout[1].
