PROTAC TEAD1/IAP degrader-1 (Compound A232) is a selective TEAD1 and cIAP1 PROTAC degrader, with DC50 values of 14 nM and 270 nM, respectively. PROTAC TEAD1/IAP degrader-1 promotes the ubiquitination and degradation of TEAD1 and cIAP1. PROTAC TEAD1/IAP degrader-1 downregulates the expression of the TEAD-dependent gene CTGF. PROTAC TEAD1/IAP degrader-1 exhibits anticancer activity against mesothelioma[1].
Molekulargewicht:
910.96
Formel:
C46H45F3N8O7S
Target-Kategorie:
IAP,PROTACs,YAP
Anwendungsbeschreibung:
MCE Product type: Reference compound
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